Second Impact Syndrome (SIS) occurs when an athlete who sustains a head injury - often a concussion or worse injury, such as a cerebral contusion (bruised brain) - sustains a second head injury before symptoms associated with the first have cleared. Typically, the athlete suffers post-concussion signs and symptoms after the first head injury, such as headache, visual, motor or sensory changes or mental difficulty, especially with the thought and memory process. Before these symptoms have cleared, which may take minutes, hours, days or weeks, the athlete returns to competition and receives a second blow to the head.